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FLRT3

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Anti-FLRT3 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Flrt3 functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. It is expressed in many tissues. Diseases associated with it include Hypogonadotropic Hypogonadism 21 With Or Without Anosmia and Kallmann Syndrome.
Protein class

Disease related genes, Human disease related genes

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Alveolar cells type 1, Basal prostatic cells, Alveolar cells type 2, Club cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AF22, hTCEpi, RPTEC TERT1, WM-115)

Interaction

Monomer and homodimer. Self-associates (via leucine-rich repeats), giving rise to homooligomers (PubMed:26235030). Interacts with FGFR1. Interacts (via extracellular domain) with ADGRL1/LPHN1 and LPHN2 (via olfactomedin-like domain) (By similarity). Interacts (via extracellular domain) with ADGRL3 (via olfactomedin-like domain); the interaction is direct (PubMed:26235030). Interacts (via extracellular domain) with UNC5B and UNC5D (via extracellular domain); the interaction is direct (PubMed:26235030). Identified in complexes composed of FLRT3, ADGRL3 and UNC5B, respectively FLRT3, ADGRL3 and UNC5D (PubMed:26235030). May also interact (via extracellular domain) with UNC5A and UNC5C. Interacts (via cytoplasmic domain) with ROBO1 (By similarity).

Molecular function

Developmental protein

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