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FZD7
Anti-FZD7 Recombinant Antibody Products
- Human Anti-FZD7 Recombinant Antibody (TAB-034CQ) (TAB-034CQ)
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- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA, IF
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- Human Anti-FZD7 Recombinant Antibody; scFv Fragment (TAB-034CQ-S(P)) (TAB-034CQ-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, IF
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- Human Anti-FZD7 Recombinant Antibody; Fab Fragment (TAB-034CQ-F(E)) (TAB-034CQ-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, IF
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- Mouse Anti-FZD7 Recombinant Antibody (TAB-033CQ) (TAB-033CQ)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC, WB
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- Mouse Anti-FZD7 Recombinant Antibody; Fab Fragment (TAB-033CQ-F(E)) (TAB-033CQ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, WB
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- Mouse Anti-FZD7 Recombinant Antibody; scFv Fragment (TAB-033CQ-S(P)) (TAB-033CQ-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, WB
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For Research Use Only. Not For Clinical Use.
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
Protein class
G-protein coupled receptors, Human disease related genes
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Breast myoepithelial cells, Breast glandular cells, Fibroblasts, Proximal enterocytes, Cardiomyocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BJ, BJ hTERT+, CAPAN-2)
Interaction
Interacts with MAGI3 (By similarity). Interacts with DVL1 (By similarity). Interacts with CCDC88C/DAPLE; the interaction displaces DVL1 from FZD7, leading to inhibition of canonical Wnt signaling and triggering of non-canonical Wnt responses (PubMed:26126266). Interacts with MYOC (PubMed:19188438). Binds to SDCBP; this interaction is increased by inositol trisphosphate (IP3) (PubMed:27386966). Interacts with glypican GPC3 (PubMed:24496449). (Microbial infection) Interacts with C.difficile toxin TcdB; frizzled receptors constitute the major host receptors for TcdB in the colonic epithelium.
Molecular function
Developmental protein, G-protein coupled receptor, Receptor, Transducer
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