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FZR1
Anti-FZR1 Recombinant Antibody Products
- Recombinant Mouse Anti-Human FZR1 Antibody (MOB-2421MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
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- Mouse Anti-FZR1 Recombinant Antibody (VS3-WK1214) (VS3-WK1214)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
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- Mouse Anti-FZR1 Recombinant Antibody (VS3-FY2714) (VS3-FY2714)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.
FZR1 (Fizzy And Cell Division Cycle 20 Related 1) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Innate Immune System. An important paralog of this gene is CDC20.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
The unphosphorylated form interacts with APC/C during mitosis (PubMed:26083744, PubMed:9734353). Interacts with NINL (PubMed:17403670). Interacts (in complex with the anaphase promoting complex APC) with MAD2L2; inhibits FZR1-mediated APC/C activation (PubMed:11459825, PubMed:11459826). Interacts with SIRT2 and USP37 (PubMed:21596315, PubMed:22014574). Interacts (via WD repeats) with MAK (PubMed:21986944). Interacts with RBBP8/CtIP; this interaction leads to RBBP8 proteasomal degradation (PubMed:25349192). Interacts with HECW2 (PubMed:24163370). Interacts with SASS6; the interaction is regulated by CENATAC and leads to SASS6 proteasomal degradation (PubMed:31722219). Interacts (via N-terminus) with CCNF (PubMed:27653696). Interacts with CDC6 (PubMed:26818844). Interacts with TK1 (via the KEN box) (PubMed:14701726).
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