FcγRII & LDL

Low-density lipoprotein (LDL) is one of the five major groups of lipoproteins. Lipoproteins are complex particles composed of multiple proteins which transport all fat molecules (lipids) around the body within the water outside cells. They are typically composed of 80-100 proteins/particle (organized by a single ApoB for LDL and the larger particles) and transporting about 3,000 to 6,000 fat molecules/particle. The fats carried include cholesterol, phospholipids, and triglycerides; amounts of each quite variable.

The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.