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GCLM
Anti-GCLM Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Protein class
Cancer-related genes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Prostatic glandular cells, Urothelial cells, Erythroid cells, Basal prostatic cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Heterodimer of a catalytic heavy chain and a regulatory light chain.
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