GEMIN2

Formats

Anti-GEMIN2 Recombinant Antibody Products

Mouse Anti-GEMIN2 Recombinant Antibody (clone 20A9) (MOB-2142z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, ICC, IF, IP
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Rabbit Anti-GEMIN2 Recombinant Antibody (VS13-YC442) (VS13-YC442)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.

This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Early spermatids, Late spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Monomer (PubMed:26092730). Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP (PubMed:11714716, PubMed:9323129, PubMed:16314521, PubMed:17178713). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG (PubMed:18984161, PubMed:9323129, PubMed:16314521). Interacts with GEMIN5; the interaction is direct (PubMed:11714716). Interacts (via C-terminus) with SMN1; the interaction is direct (PubMed:21816274, PubMed:26092730, PubMed:10500148, PubMed:31799625, PubMed:17178713, PubMed:22607171, PubMed:23022347). Interacts with GEMIN5; the interaction is direct (PubMed:17178713). Interacts with SNRPD1; the interaction is direct (PubMed:21816274, PubMed:31799625). Interacts with SNRPD2; the interaction is direct (PubMed:21816274, PubMed:31799625). Interacts (via N-terminus) with SNRPF; the interaction is direct (PubMed:21816274, PubMed:31799625). Interacts (via N-terminus) with SNRPE; the interaction is direct (PubMed:21816274, PubMed:31799625). Interacts (via N-terminus) with SNRPG; the interaction is direct (PubMed:21816274).

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