GJB2

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Anti-GJB2 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs offers a comprehensive selection of validated anti-GJB2 recombinant antibodies. These high-quality reagents are rigorously validated to ensure optimal performance in a variety of applications, including Western blotting, immunohistochemistry, immunofluorescence, and ELISA. By leveraging our expertise in recombinant antibody technology, we provide researchers with reliable tools to advance their studies in cell biology, disease modeling, and drug discovery.

GJB2: An Important Target for Cancer Therapy

The GJB2 gene encodes connexin 26, a protein involved in cell-to-cell communication. Beyond its role in normal cellular function, connexin 26 has been implicated in cancer development and progression. Abnormal expression of connexin 26 has been linked to various cancers, including colorectal, breast, and bladder cancer. Overexpression of connexin 26 can increase cancer cell motility, invasion, and stem cell-like features. Given its potential role in cancer, targeting connexin 26 presents a promising therapeutic strategy for cancer treatment.

Alternative Names

CX26; CXB2_HUMAN; DFNA3; DFNB1; gap junction protein, beta 2, 26kDa; NSRD1; Gap Junction Beta-2 Protein; Connexin 26; Mutant Gap Junction Beta 2 Protein; BAPS 3; Cx26 4; HID 3; KID 3; PPK.

Background

This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness.

Anti-GJB2 rAb Products

Creative Biolabs offers a diverse spectrum of recombinant anti-GJB2 antibodies that have been rigorously developed to provide maximum specificity and affinity. These antibodies are appropriate for a variety of research applications, including basic research and therapeutic development, and come in a variety of forms. Our innovative platform enables us to provide high-quality tools that improve our understanding of cellular and molecular biology, with a particular emphasis on immunology and cancer research.

Table 1. Featured anti-GJB2 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs offers a comprehensive range of validated anti-GJB2 recombinant antibodies. These antibodies are engineered to exhibit exceptional specificity, stability, and efficacy. Our stringent quality control measures guarantee that every antibody fulfills the highest industry requirements. These high-quality antibodies are invaluable tools for researchers investigating the role of connexin 26 in cancer research.

Fig.1 SDS-PAGE analysis of anti-GITR antibody
(Cat# PABC-396, Creative Biolabs).

Customer Reviews

Excellent

Eg***t
Human Anti-GJB2 Recombinant Antibody (clone abEC1.1) (PABC-396)

As a researcher focused on genetic hearing disorders, I have found Creative Biolabs' anti-GJB2 recombinant antibodies to be invaluable in my studies. The quality of the antibodies is exceptional, providing consistent results across multiple experiments. They show high specificity and binding affinity, which have significantly enhanced our ability to accurately detect the GJB2 protein in various samples. The product is also stable over time, maintaining its integrity even after repeated freeze-thaw cycles, which is crucial for my long-term projects.

26/Aug/2023

Excellent

Fr***n
Human Anti-GJB2 Recombinant Antibody (clone abEC1.1); Fab Fragment (PFBC-396)

Our lab has been using Creative Biolabs' anti-GJB2 recombinant antibodies for several months, primarily for immunohistochemistry. The results have been consistently reliable, with clean and clear staining, allowing us to draw precise conclusions from our data. The antibodies are easy to use, and the technical support provided by Creative Biolabs has been top-notch, assisting us promptly with optimization protocols.

6/Mar/2024

Excellent

Th***s
Mouse Anti-GJB2 Recombinant Antibody (clone 24H11) (MOB-2985z)

Working with the anti-GJB2 recombinant antibodies from Creative Biolabs has been a positive experience due to their high responsiveness and thorough customer support. Initially, we faced some challenges in adjusting the concentration for our Western blot assays, but the detailed documentation and assistance from their team made it easy to resolve. The antibodies exhibit robust specificity and have proven essential in confirming GJB2 expression levels in our cell line models. The availability of batch testing data further instills confidence in their products. It's reassuring to have dependable support and reliable materials in cutting-edge research.

11/Oct/2024

rAb Production

Creative Biolabs employs innovative genetic engineering techniques to produce excellent in quality anti-GJB2 antibodies, guaranteeing a consistent supply for a wide range of research applications.

Featured Anti-GJB2 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-GJB2 recombinant antibody production.

Fig.3 Gram-scale anti-GJB2 recombinant antibody production.

rAb Modalities

Creative Biolabs offers an extensive range of premium anti-GJB2 recombinant antibodies designed to cater to research needs worldwide.

Fig.4 Full-length anti-GJB2 recombinant antibody production and modalities.

GJB2-Targeted Drug Information

Table 2. Public drug targeting GJB2.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

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