Recombinant Anti-GJB2 Vesicular Antibody, EV Displayed (VS-0425-YC424)
CAT#: VS-0425-YC424
The Recombinant Anti-GJB2 Vesicular Antibody, EV Displayed (VS-0425-YC424) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to GJB2-expressed cells or tissues. The GJB2 is a connexin protein forming gap junctions, with mutations linked to hearing loss.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14362/1560_F3_3_selected.jpg
Normal Tissue
Figure 2 Esophagus
Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13093/33277_B_6_1.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13093/33277_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13093/33277_A_8_4.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13093/33277_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (CAPAN-2, hTCEpi, OE19, RT4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165474-GJB2
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Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- GJB2
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Gap junction protein beta 2
- Biological Process
- Hearing
- Cellular Localization
- Mitochondria
- Introduction
- This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008]
- Alternative Names
- CX26, DFNA3, DFNB1, NSRD1
- Gene ID
- 2706
- UniProt ID
- P29033
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "GJB2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2985z | Mouse Anti-GJB2 Recombinant Antibody (clone 24H11) | WB, ELISA, IHC | Mouse IgG1, κ |
| PABC-396 | Human Anti-GJB2 Recombinant Antibody (clone abEC1.1) | ELISA, WB, IF, Inhib | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-396 | Human Anti-GJB2 Recombinant Antibody (clone abEC1.1); Fab Fragment | ELISA, WB, IF, Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-396 | Human Anti-GJB2 Recombinant Antibody (clone abEC1.1); scFv Fragment | ELISA, WB, IF, Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY123 | Human Anti-GJB2 (clone abEC1.1) scFv-Fc Chimera | ELISA, WB, IF, Inhib | Human IgG1, scFv-Fc |
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