Human Anti-GJB2 Recombinant Antibody (clone abEC1.1); Fab Fragment
CAT#: PFBC-396
This product is a recombinant Human antibody Fab fragment that can recognize Connexin26. The antibody binds an extracellular epitope of Cx26. abEC1.1 inhibits connexin hemichannels by binding an epitope at the apex of the EC1 loop.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14362/1560_F3_3_selected.jpg
Normal Tissue
Figure 2 Esophagus
Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13093/33277_B_6_1.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13093/33277_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13093/33277_A_8_4.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13093/33277_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (CAPAN-2, hTCEpi, OE19, RT4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165474-GJB2
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Specifications
- Immunogen
- A peptide corresponding to residues 41-56 of Cx26
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human Fab
- Specificity
- Human GJB2
- Species Reactivity
- Human
- Clone
- abEC1.1
- Applications
- ELISA, WB, IF, Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Clone abEC1.1"
- CAT
- Product Name
See other products for "GJB2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2985z | Mouse Anti-GJB2 Recombinant Antibody (clone 24H11) | WB, ELISA, IHC | Mouse IgG1, κ |
| PABC-396 | Human Anti-GJB2 Recombinant Antibody (clone abEC1.1) | ELISA, WB, IF, Inhib | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-396 | Human Anti-GJB2 Recombinant Antibody (clone abEC1.1); scFv Fragment | ELISA, WB, IF, Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY123 | Human Anti-GJB2 (clone abEC1.1) scFv-Fc Chimera | ELISA, WB, IF, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC424 | Recombinant Anti-GJB2 Vesicular Antibody, EV Displayed (VS-0425-YC424) | ELISA, FC, Inhib, Cell-uptake |
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