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For Research Use Only. Not For Clinical Use.
Cancer-related genes
Intracellular
Low cell type specificity
Low immune cell specificity
Low cell line specificity
Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with PUF60. (Microbial infection) interacts with Rift valley fever virus NSs (via OmegaXaV motif).