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HDGF
Anti-HDGF Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Protein class
Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Monomer, and domain-swapped homodimer (PubMed:17270212). [Isoform 1]: Interacts with nuclear proteins NCL and YBX1/YB1 (PubMed:26845719). [Isoform 2]: Interacts with cytoskeletal proteins such as actin, dynein, tubulin and vimentin (PubMed:26845719). [Isoform 3]: Interacts with cytoskeletal proteins such as dynein and tubulin but does not interact with actin or vimentin (PubMed:26845719).
Molecular function
DNA-binding, Growth factor, Heparin-binding, Repressor
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