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HLA-E
Anti-HLA-E Recombinant Antibody Products
- Mouse Anti-HLA-E Recombinant Antibody (clone F21-2) (NEUT-910CQ)
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- Species Reactivity: Avian, Chicken, Turkey
- Type: Mouse IgG1, κ
- Application: WB, Neut, FC, IHC, IHC-Fr, IP
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For Research Use Only. Not For Clinical Use.
HLA-E is another gene within the MHC class I family, but unlike other MHC class I molecules, it primarily presents peptides derived from the leader sequences of other MHC class I molecules. Its primary role is to interact with inhibitory receptors on NK (natural killer) cells and CD8+ T cells, helping to regulate immune responses. HLA-E is involved in immune tolerance, protecting healthy cells from immune attack. Variations in HLA-E can affect the immune response, influencing susceptibility to infections and diseases, including autoimmune conditions.
Protein class
Plasma proteins
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Adipocytes, NK-cells, Hepatic stellate cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (ASC diff, U-266/70)
Interaction
Forms a heterotrimer with B2M and a self- or a pathogen-derived peptide (peptide-bound HLA-E-B2M) (PubMed:18339401, 30087334). Similarly to MHC class Ia assembly, HLA-E-B2M heterodimer interacts with components of the antigen processing machinery TAPBP and TAP1-TAP2 complex; this interaction is required for peptide loading and translocation to the cell surface (PubMed:9427624). Interacts with CALCR; this interaction is required for appropriate folding (PubMed:9427624). The optimum binding peptide is a nonamer (VL9) that is primarily derived from amino-acid residues 3-11 of the signal sequences of most HLA-A, -B, -C and -G molecules (PubMed:9754572, 18083576, 9660937, 18339401). The VL9 peptide anchors to five main sites in the peptide-binding groove of HLA-E (PubMed:18339401). Peptide-bound HLA-E-B2M complex interacts with KLRD1-KLRC1 receptor on NK cells (PubMed:9486650, 18083576). Binds with lower affinity to activating KLRD1-KLRC2 (PubMed:18083576, 23335510). The common subunit KLRC1 plays a prominent role in directly interacting with HLA-E (PubMed:18083576). Peptide-bound HLA-E-B2M interacts with the alpha-beta TCR on unconventional CD8+ T cells (PubMed:16474394). Peptide-free HLA-E interacts with HLA-F-B2M complex; this interaction may regulate the intracellular trafficking and the stability of peptide-free MHC class I open conformers (OCs).
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