HSV VP16

Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the herpesvirus family, Herpesviridae, that infect humans. Both HSV-1 (which produces most cold sores) and HSV-2 (which produces most genital herpes) are ubiquitous and contagious. They can be spread when an infected person is producing and shedding the virus. In simple terms, herpes simplex 1 is most commonly known as a "cold sore," while herpes simplex 2 is the one known by the public as "herpes," or "genital herpes." Herpes simplex 1 is known to infect about 95% of the human populace, and is treated less seriously than herpes simplex 2, even though both are incurable. VP16 from herpes simple virus (HSV) is a strong transcriptional activator of immediate early viral genes.