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HTR2A
Anti-HTR2A Recombinant Antibody Products
- Mouse Anti-HTR2A Recombinant Antibody (clone CBH621) (MOB-327YJL)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ICC, IHC, IP
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For Research Use Only. Not For Clinical Use.
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class
FDA approved drug targets, G-protein coupled receptors, Human disease related genes
Predicted location
Membrane
Single cell type specificity
Cell type enriched (Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (ASC diff, ASC TERT1, BEWO, HEL, U-138 MG, U-2 OS, U-87 MG)
Interaction
Interacts (via C-terminus) with MPDZ and PATJ (PubMed:11150294, PubMed:14988405). May interact (via C-terminus) with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2 (PubMed:14988405). Interacts with GRM2 and DRD2; this may affect signaling (PubMed:18297054, PubMed:21645528, PubMed:22300836).
Molecular function
G-protein coupled receptor, Host cell receptor for virus entry, Receptor, Transducer
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