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IL16
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Glyco-Engineering Antibody Products
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Anti-IL16 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants.
Protein class
Cancer-related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (B-cells, NK-cells, Langerhans cells, dendritic cells, T-cells, Kupffer cells, Plasma cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Daudi, HEL, HMC-1, RPMI-8226, U-266/70, U-698, U-937)
Interaction
Homotetramer (Probable). According to PubMed:9699630, the formation of a homotetrameric protein complex is not required for the chemo-attractant function. Isoform 3 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GRIN2A. Isoform 3 interacts with GABPB1. Isoform 3 interacts (via PDZ 3 domain) with HDAC3. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C (By similarity). (Microbial infection) Isoform 3 interacts with HTLV-1 tax.
Molecular function
Cytokine
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