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IMPDH1
Anti-IMPDH1 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene.
Protein class
Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Rod photoreceptor cells, Bipolar cells, Cone photoreceptor cells, Horizontal cells)
Immune cell specificity
Group enriched (neutrophil, non-classical monocyte, intermediate monocyte, eosinophil, classical monocyte, myeloid DC)
Cell line specificity
Cell line enhanced (SK-BR-3)
Interaction
Homotetramer.
Molecular function
DNA-binding, Oxidoreductase, RNA-binding
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