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IRF7
Anti-IRF7 Recombinant Antibody Products
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- Species Reactivity: Human, Mouse, Rat, Zebrafish
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
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- Rabbit Anti-IRF7 Recombinant Antibody (VS3-WK1091) (VS3-WK1091)
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat, Zebrafish
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP, FC
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For Research Use Only. Not For Clinical Use.
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (dendritic cells)
Immune cell specificity
Immune cell enriched (plasmacytoid DC)
Cell line specificity
Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, Karpas-707)
Interaction
Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF3 (PubMed:17574024). Interacts with TICAM1 and TICAM2. Interacts with MYD88 and TRAF6. Interacts with TRIM35 (PubMed:25907537, PubMed:11073981, PubMed:11314014, PubMed:14517278, PubMed:14739303, PubMed:15361868, PubMed:15492225). Interacts with NMI; the interaction is direct and leads to the inhibition of IRF7-mediated type I IFN production (By similarity). (Microbial infection) Interacts with Epstein-Barr virus LF2 and LMP1. (Microbial infection) Interacts with rotavirus A NSP1; this interaction leads to the proteasome-dependent degradation of IRF7. (Microbial infection) Interacts with human herpes virus 8/HHV-8 proteins ORF45 and vIRF-1. (Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein HBZ. (Microbial infection) Interacts with Seneca Valley virus protease 3C; this interaction is involved in the suppression of IRF7 expression and phosphorylation by the virus. (Microbial infection) Interacts with ebolavirus VP35; this interaction mediates the sumoylation of IRF7 and contributes to the viral inhibition of IFN-type I production.
Molecular function
Activator, DNA-binding
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Related Signaling Pathways
TLR Signaling Pathway