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Integrin α5β1
Anti-Integrin α5β1 Recombinant Antibody Products
- Human Anti-Integrin α5β1 Recombinant Antibody (HPAB-0392-CN) (HPAB-0392-CN)
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- Derivation: Human
- Species Reactivity: Human
- Type: Chimeric (hamster/human) IgG1, κ
- Application: ELISA
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- Human Anti-Integrin α5β1 Recombinant Antibody (HPAB-0393-CN) (HPAB-0393-CN)
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- Derivation: Human
- Species Reactivity: Human
- Type: Humanized IgG3, λ
- Application: ELISA
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- Human Anti-Integrin α5β1 Recombinant Antibody (HPAB-0394-CN) (HPAB-0394-CN)
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- Derivation: Human
- Species Reactivity: Human
- Type: Humanized IgG3, λ
- Application: ELISA
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- Human Anti-Integrin α5β1 Recombinant Antibody (clone 2H12) (HPAB-0786-CN)
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- Derivation: Human
- Type: Human IgG4, κ
- Application: ELISA, FC
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- Human Anti-Integrin α5β1 Recombinant Antibody (HPAB-J0148-YC) (HPAB-J0148-YC)
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- Derivation: Chimeric (hamster/human)
- Species Reactivity: Human
- Type: Chimeric (hamster/human) IgG
- Application: ELISA, FuncS
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- Human Anti-Integrin α5β1 Recombinant Antibody scFv Fragment (HPAB-J0148-YC-S(P)) (HPAB-J0148-YC-S(P))
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- Species Reactivity: Human
- Type: Hamster scFv
- Application: ELISA, Inhib, FuncS
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- Human Anti-Integrin α5β1 Recombinant Antibody Fab Fragment (HPAB-J0148-YC-F(E)) (HPAB-J0148-YC-F(E))
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- Derivation: Chimeric (hamster/human)
- Species Reactivity: Human
- Type: Chimeric (hamster/human) Fab
- Application: ELISA, Inhib, FuncS
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- Human Anti-Integrin α5β1 Recombinant Antibody (clone 2H12); scFv Fragment (HPAB-0786-CN-S(P))
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- Derivation: Human
- Type: Human scFv
- Application: ELISA, FC
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- Human Anti-Integrin α5β1 Recombinant Antibody (clone 1F2.2B7); scFv Fragment (HPAB-0787-CN-S(P))
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- Derivation: Human
- Type: Human scFv
- Application: ELISA, FC
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- Human Anti-Integrin α5β1 Recombinant Antibody (clone 2H12IgG1TM); scFv Fragment (HPAB-0788-CN-S(P))
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- Derivation: Human
- Type: Human scFv
- Application: ELISA, FC
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- Human Anti-Integrin α5β1 Recombinant Antibody; scFv Fragment (HPAB-0393-CN-S(P)) (HPAB-0393-CN-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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- Human Anti-Integrin α5β1 Recombinant Antibody; scFv Fragment (HPAB-0394-CN-S(P)) (HPAB-0394-CN-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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- Human Anti-Integrin α5β1 Recombinant Antibody; Fab Fragment (HPAB-0392-CN-F(E)) (HPAB-0392-CN-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Human Anti-Integrin α5β1 Recombinant Antibody; Fab Fragment (HPAB-0393-CN-F(E)) (HPAB-0393-CN-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Human Anti-Integrin α5β1 Recombinant Antibody; Fab Fragment (HPAB-0394-CN-F(E)) (HPAB-0394-CN-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Human Anti-Integrin α5β1 Recombinant Antibody; scFv Fragment (HPAB-0392-CN-S(P)) (HPAB-0392-CN-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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- Human Anti-Integrin α5β1 Recombinant Antibody (clone 2H12); Fab Fragment (HPAB-0786-CN-F(E))
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- Derivation: Human
- Type: Human Fab
- Application: ELISA, FC
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- Human Anti-Integrin α5β1 Recombinant Antibody (clone 1F2.2B7); Fab Fragment (HPAB-0787-CN-F(E))
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- Derivation: Human
- Type: Human Fab
- Application: ELISA, FC
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- Human Anti-Integrin α5β1 Recombinant Antibody (clone 2H12IgG1TM); Fab Fragment (HPAB-0788-CN-F(E))
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- Derivation: Human
- Type: Human Fab
- Application: ELISA, FC
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For Research Use Only. Not For Clinical Use.
This is a fully human, fragment crystalizable (Fc)-engineered IgG1 mAb, which specifically neutralizes α5 and binds the Fcγ receptors (FcγR) with enhanced affinity. In vitro, PF-5412 potently inhibited α5β1-mediated intracellular signaling, cell adhesion, migration, and endothelial cell (EC) tubulogenesis. The dual mechanism of action and robust antitumor efficacy of PF-5412 support its clinical development for the treatment of a broad spectrum of human malignancies.