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JAG1
Anti-JAG1 Recombinant Antibody Products
- Recombinant Mouse Anti-JAG1 Antibody (CBL581) (NEUT-1609CQ)
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- Species Reactivity: Human
- Type: IgG2b
- Application: Neut
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- Recombinant Mouse Anti-JAG1 Antibody (4A24) (NEUT-1608CQ)
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- Species Reactivity: Human
- Type: IgG2
- Application: FC, Neut
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- Recombinant Mouse Anti-JAG1 Antibody (CBL125) (NEUT-1607CQ)
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- Species Reactivity: Human
- Type: IgG2
- Application: FC, WB, Neut
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For Research Use Only. Not For Clinical Use.
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
Protein class
CD markers, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Squamous epithelial cells, Basal squamous epithelial cells, Endometrial ciliated cells, Smooth muscle cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HBEC3-KT, hTERT-HME1, U-251 MG)
Interaction
Interacts with NOTCH2 and NOTCH3 (By similarity). Interacts with NOTCH1 (in the presence of calcium ions) (PubMed:18660822).
Molecular function
Developmental protein
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Related Signaling Pathways
TNF Signaling Pathway