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KCNK1
Anti-KCNK1 Recombinant Antibody Products
- Rabbit Anti-KCNK1 Polyclonal Antibody (MRO-1991-CN) (MRO-1991-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, FC
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For Research Use Only. Not For Clinical Use.
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]
Protein class
Voltage-gated ion channels
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Urothelial cells, Prostatic glandular cells, Horizontal cells, Excitatory neurons)
Immune cell specificity
Immune cell enriched (plasmacytoid DC)
Cell line specificity
Cell line enhanced (HeLa, SCLC-21H, U-266/70, U-266/84)
Interaction
Homodimer; disulfide-linked (PubMed:8978667, PubMed:22282804). Heterodimer with KCNK2; disulfide-linked (By similarity). In astrocytes, forms mostly heterodimeric potassium channels with KCNK2, with only a minor proportion of functional channels containing homodimeric KCNK1 (By similarity). Interacts with KCNK3 and KCNK9, forming functional heterodimeric channels (PubMed:23169818). Interacts with GNG4 (By similarity). Identified in a complex with PSD and ARF6; interacts only with PSD that is bound to ARF6 (By similarity). Interacts with UBE2I (PubMed:15820677).
Molecular function
Ion channel, Potassium channel
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