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LCK
Loading...Anti-LCK ProductsBackground
Anti-LCK Products
- Mouse Anti-LCK Recombinant Antibody (clone 25C4) (MOB-1482z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FC, ICC, IHC, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, IHC, ICC, FC, ELISA
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- Mouse Anti-LCK Recombinant Antibody (VS3-CJ434) (VS3-CJ434)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ICC, IHC, FC
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- Mouse Anti-LCK Recombinant Antibody (VS3-FY2938) (VS3-FY2938)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB, IHC, ICC, FC
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- Mouse Anti-Lck Monoclonal Antibody (clone 8E5F9) (VS7-0425-WR280)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (NK-cells, T-cells, dendritic cells)
Immune cell specificity
Group enriched (T-reg, naive CD4 T-cell, memory CD8 T-cell, naive CD8 T-cell, memory CD4 T-cell, gdT-cell, MAIT T-cell, NK-cell)
Cell line specificity
Group enriched (JURKAT, MOLT-4, U-698)
Interaction
Binds to the cytoplasmic domain of cell surface receptors, such as AXL, CD2, CD4, CD5, CD8, CD44, CD45 and CD122. Also binds to effector molecules, such as PI4K, VAV1, RASA1, FYB1 and to other protein kinases including CDK1, RAF1, ZAP70 and SYK. Binds to phosphatidylinositol 3'-kinase (PI3K) from T-lymphocytes through its SH3 domain and to the tyrosine phosphorylated form of KHDRBS1/p70 through its SH2 domain. This interaction inhibits its tyrosine-kinase activity. Interacts with SQSTM1. Interacts with phosphorylated LIME1. Interacts with CBLB and PTPRH. Interacts with RUNX3. Forms a signaling complex with EPHA1, PTK2B AND PI3-KINASE; upon activation by EFNA1 which may regulate T-lymphocyte migration. Associates with ZAP70 and RHOH; these interactions allow LCK-mediated RHOH and CD3 subunit phosphorylation in the presence of functional ZAP70. Interacts with UNC119; this interaction plays a crucial role in activation of LCK. Interacts with CEACAM1 (via cytoplasmic domain); mediates CEACAM1 phosphorylation resulting in PTPN6 recruitment that dephosphorylates TCR stimulation-induced CD247 and ZAP70 (PubMed:18424730). Interacts with CD160. Interacts with CD48 (PubMed:12007789). (Microbial infection) Interacts with herpes simplex virus 1 UL46; this interaction activates LCK. (Microbial infection) Interacts with HIV-1 Nef through its SH3 domain.
Molecular function
Kinase, Transferase, Tyrosine-protein kinase
More Types Infomation
Related Signaling Pathways
TCR Signaling Pathway
Related Diseases
Primary Immunodeficiency