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LDLR
Anti-LDLR Recombinant Antibody Products
- Chicken Anti-LDLR Polyclonal IgY (BRD-0323MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: Anti-LDLR antibody produced in chicken is suitable for WBting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ICC/IF, WB, IP, FC, IHC-P
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- Rabbit Anti-LDLR Recombinant Antibody (clone AFY0057) (MOR-0086-FY)
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: FC, ICC, IHC, WB
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For Research Use Only. Not For Clinical Use.
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Alveolar cells type 2, Alveolar cells type 1)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Low cell line specificity
Interaction
Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity). Interacts (via NPXY motif) with LDLRAP1 (via PID domain) (PubMed:12221107, 22509010). Interacts with ARRB1 (PubMed:12944399). Interacts with SNX17 (PubMed:14739284). Interacts with the full-length immature form of PCSK9 (via C-terminus) (PubMed:17461796, 21149300). (Microbial infection) Interacts with C. difficile toxin TcdA, suggesting that it may contribute to TcdA toxin entry into cells. (Microbial infection) Interacts with vesicular stomatitis virus glycoprotein. (Microbial infection) May interact with HIV-1 Tat.
Molecular function
Host cell receptor for virus entry, Receptor
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Related Diseases
Cushing Syndrome