LDLR

AbPlus Recombinant Antibody Products Formats

Anti-LDLR Recombinant Antibody Products

Recombinant Anti-LDLR Vesicular Antibody, EV Displayed (VS-0425-YC636) (VS-0425-YC636)
- Species Reactivity: Human, Mouse, Rat
- Target: LDLR
- Host Animal: Mouse
- Application: ELISA, FC, Cell-uptake
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For Research Use Only. Not For Clinical Use.

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.

Protein class

Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Alveolar cells type 2, Alveolar cells type 1)

Immune cell specificity

Immune cell enriched (basophil)

Cell line specificity

Low cell line specificity

Interaction

Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity). Interacts (via NPXY motif) with LDLRAP1 (via PID domain) (PubMed:12221107, 22509010). Interacts with ARRB1 (PubMed:12944399). Interacts with SNX17 (PubMed:14739284). Interacts with the full-length immature form of PCSK9 (via C-terminus) (PubMed:17461796, 21149300). (Microbial infection) Interacts with C. difficile toxin TcdA, suggesting that it may contribute to TcdA toxin entry into cells. (Microbial infection) Interacts with vesicular stomatitis virus glycoprotein. (Microbial infection) May interact with HIV-1 Tat.

Molecular function

Host cell receptor for virus entry, Receptor

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Related Diseases

Cushing Syndrome