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For Research Use Only. Not For Clinical Use.
Human disease related genes, Transporters
Intracellular, Membrane (different isoforms)
Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Inhibitory neurons)
Low immune cell specificity
Low cell line specificity
Heterohexamer (PubMed:32415200). Oligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8C and/or LRRC8E) to form a heterohexamer (PubMed:24782309, 26530471, 28193731, 26824658). In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist (Probable).
Ion channel