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LRRK2
Anti-LRRK2 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Alveolar cells type 2, Oligodendrocyte precursor cells, monocytes, Excitatory neurons)
Immune cell specificity
Immune cell enriched (neutrophil)
Cell line specificity
Cell line enhanced (A549, ASC TERT1, BJ hTERT+, RPTEC TERT1, T-47d)
Interaction
Homodimer (PubMed:22952686, 18230735, 30635421). Interacts with PRKN, PRDX3, and TPCN2 (PubMed:16352719, 21850687, 22012985). Interacts with VPS35 and RAB29 (PubMed:23395371). Interacts (via ROC domain) with SEC16A (PubMed:25201882). Interacts with APP; interaction promotes phosphorylation of 'Thr-743' of APP (PubMed:28720718). Interacts with MAPT (PubMed:26014385). Interacts with RAB8A, RAB10, and RAB12 (PubMed:26824392). Interacts with YWHAG; this interaction is dependent on phosphorylation of Ser-910 and either Ser-935 or Ser-1444 (PubMed:28202711). Interacts with SFN; this interaction is dependent on phosphorylation of Ser-910 and/or Ser-935 (PubMed:28202711).
Molecular function
GTPase activation, Hydrolase, Kinase, Serine/threonine-protein kinase, Transferase
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