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MR1
Anti-MR1 Recombinant Antibody Products
- Recombinant Mouse Anti-MR1 Antibody (26.5) (NEUT-1750CQ)
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- Species Reactivity: Human, Mouse, Rat, Bovine (Cow)
- Type: IgG2a, κ
- Application: FC, ELISA, IP, BL
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For Research Use Only. Not For Clinical Use.
MR1 (MHC class I-related gene) encodes a protein that presents microbial-derived antigens to mucosal-associated invariant T (MAIT) cells, a unique subset of T cells involved in immune responses. MR1 is essential for the recognition of vitamin B2-derived metabolites produced by bacteria and fungi. The MR1-MAIT cell interaction plays a critical role in the body's defense against infections.
Protein class
FDA approved drug targets
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Heterotrimer that consists of MR1, B2M and a metabolite antigen (PubMed:27043408, PubMed:23051753, PubMed:23846752, PubMed:24695216). Forms reversible covalent Schiff base complexes with the microbial metabolite, which serves as a molecular switch triggering complete folding, stable association with B2M and translocation of the ternary complex from endoplasmic reticulum to the plasma membrane (PubMed:27043408, PubMed:23051753, PubMed:23846752, PubMed:24695216). On antigen-presenting cells, the ternary complex interacts with TCR on CD8-positive T cells (PubMed:23846752, PubMed:24695216, PubMed:26795251). The molecular machinery involved in antigen processing remains unknown, but appears to be TAP1-TAP2 and proteasome-independent. Structurally, MR1-B2M heterodimer adopts a topology similar to classical MHC class I molecules, with alpha-1 and alpha-2 domains of MR1 forming the antigen-binding cleft composed of two alpha-helices resting on a floor of 7-stranded anti-parallel beta-pleated sheet (PubMed:23846752, PubMed:24695216, PubMed:26795251). The ribityl moiety of pyrimidine-based antigens is recognized by Tyr-95 residue in the CDR3 alpha loop of the invariant TRAV1-2 TCR (PubMed:23846752, PubMed:24695216, PubMed:26795251). [Isoform 3]: Homodimerizes and does not associate with B2M.
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