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MVP
Anti-MVP Recombinant Antibody Products
- AbPlus™ Anti-MVP Magnetic Beads (MVP-φ4) (VS-0424-XY193)
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- Target: MVP
- Target Species: Human
- Application: IP, Protein Purification
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- AbPlus™ Anti-MVP Magnetic Beads (VS-0724-YC414) (VS-0724-YC414)
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- Target: MVP
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.
Protein class
Cancer-related genes, Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Proximal enterocytes, Distal enterocytes, Paneth cells, Exocrine glandular cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (TIME)
Interaction
The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540.
Molecular function
Ribonucleoprotein
More Types Infomation