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NDC80
Loading...Anti-NDC80 Products
- Rabbit Anti-NDC80 Polyclonal Antibody (MRO-1922-CN) (MRO-1922-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, FC
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- Recombinant Mouse Anti-NDC80 Antibody (clone 1D11B8) (VS3-FY1013)
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- Type: Mouse IgG2a
- Application: ELISA, WB, IHC, ICC, FC
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- Recombinant Mouse Anti-NDC80 Antibody (clone 2B1G6) (VS3-FY1014)
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- Type: Mouse IgG1
- Application: ELISA, WB, ICC, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: B, ICC, IF, IHC, FC, IP, FuncS
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- Mouse Anti-NHP NDC80 Recombinant Antibody (clone 9G3.23) (VS-1024-XY244)
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- Species Reactivity: Hamster, Human, Mouse, Non-human primate, Pig
- Type: Mouse IgG2a
- Application: WB, IF, IP
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- Mouse Anti-NDC80 Recombinant Antibody (clone 4B12H3) (VS7-0425-WR459)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, FC
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For Research Use Only. Not For Clinical Use.
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatocytes, Erythroid cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end. Interacts with isoform 1 of NEK2 and ZWINT specifically during mitosis. Interacts with CENPH and MIS12. May interact with AURKB, PSMC2, PSMC5 and SMC1A. May interact with RB1 during G2 phase and mitosis. Interacts with CKAP5 (PubMed:27156448). Interacts with CDT1; leading to kinetochore localization of CDT1 (PubMed:22581055).
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