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NUF2
This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatocytes, Erythroid cells, Spermatogonia)
Immune cell specificity
Immune cell enhanced (T-reg)
Cell line specificity
Low cell line specificity
Interaction
Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end. May interact with AURKB/Aurora-B. Directly interacts with CENPE; this interaction determines CENPE kinetochore localization.
More Types Infomation
- A*24:02/Human NUF2 (VYGIRLEHF) MHC Tetramer (MHC-CN1100)
-
- Class: Class I
- Antigen: NUF2
- Antigen Species: Human
- Peptide: VYGIRLEHF
- Conjugate: Unconjugated
- FITC-A*24:02/Human NUF2 (VYGIRLEHF) MHC Tetramer (MHC-CN1099)
-
- Class: Class I
- Antigen: NUF2
- Antigen Species: Human
- Peptide: VYGIRLEHF
- Conjugate: FITC
- APC-A*24:02/Human NUF2 (VYGIRLEHF) MHC Tetramer (MHC-CN1098)
-
- Class: Class I
- Antigen: NUF2
- Antigen Species: Human
- Peptide: VYGIRLEHF
- Conjugate: APC
- PE-A*24:02/Human NUF2 (VYGIRLEHF) MHC Tetramer (MHC-CN1097)
-
- Class: Class I
- Antigen: NUF2
- Antigen Species: Human
- Peptide: VYGIRLEHF
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.