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    Nucleoprotein

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    Background

    IAV NPs have been reported to interact with host and viral proteins to mediate vRNP trafficking from the cytoplasm to the nucleus and vice versa, as well as to regulate vRNA expression. The NP sequence has been shown to be conserved among IAV isolates and, therefore, the NP-host interaction is a compelling antiviral target
    Nucleoprotein
    Bovine coronavirus (BCoV) is as a member of the Coronaviridae family which are enveloped, single-stranded, positive-sense RNA viruses with a club-shaped surface. Infection causes 'Calf Enteritis' and contributes to the 'Enzootic Pneumonia complex' in calves. It can also cause 'Winter Dysentery' in adult cattle. It can infect both domestic and wild ruminants and has a worldwide distribution. Transmission is horizontal, via oro-fecal or respiratory routes.
    Canine Parainfluenza Virus (CPIV) is a single-stranded RNA virus of the virus family Paramyxoviridae. CPIV typically causes mild respiratory tract infections. It may act in conjunction with other microbial agents, resulting in canine infectious tracheobronchitis (kennel cough). Kennel cough is an acute inflammation of the upper airways that can progress to fatal pneumonia in puppies, or to chronic bronchitis in older dogs. The disease is highly contagious and spreads quickly among dogs that are housed together. The virus is transmitted via contact with the nasal secretions of infected dogs.
    Canine Parainfluenza Virus (CPIV) is a single-stranded RNA virus of the virus family Paramyxoviridae. CPIV typically causes mild respiratory tract infections. It may act in conjunction with other microbial agents, resulting in canine infectious tracheobronchitis (kennel cough). Kennel cough is an acute inflammation of the upper airways that can progress to fatal pneumonia in puppies, or to chronic bronchitis in older dogs. The disease is highly contagious and spreads quickly among dogs that are housed together. The virus is transmitted via contact with the nasal secretions of infected dogs.
    Canine distemper is caused canine distemper virus (CDV), a single-stranded RNA virus of the family Paramyxoviridae, which is a close relative of the viruses that cause measles in humans and rinderpest in animals. In canines, distemper impacts several body systems, including the gastrointestinal and respiratory tracts and the spinal cord and brain, with common symptoms that include high fever, eye inflammation and eye/nose discharge, labored breathing and coughing, vomiting and diarrhea, loss of appetite and lethargy, and hardening of nose and footpads. The viral infection can be accompanied by secondary bacterial infections and can present eventual serious neurological symptoms.
    Newcastle disease is a contagious viral bird disease affecting many domestic and wild avian species. Newcastle disease virus (NDV) is a variant of avian paramyxovirus 1 (APMV-1), a negative-sense,single-stranded RNA virus. NDV/APMV-1 belong to the genus Avulavirus in the family Paramyxoviridae. NDV selectively replicates in and destroys human tumor cells without affecting normal cells and thus provides a potential therapeutic approach for treating human cancers.The nucleocapsid protein (NP) was the most abundant structure protein in the viral particle and can be served as the diagnostic target.
    Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).
    Canine respiratory coronavirus (CRCoV) which was previously regarded as group II CCoV was recently found to be similar to strain OC43 of bovine and human coronaviruses. It was first isolated in the United Kingdom in 2003 from lung samples of dogs and has since been found on the European mainland and in Japan. A serological study in 2006 has also shown antibodies to CRCoV to be present in dogs in Canada and the United States. However, a retrospective study in Saskatchewan found that CRCoV may have been present there as far back as 1996.
    Nucleoproteins are any proteins that are structurally associated with nucleic acids, either DNA or RNA. Typical nucleoproteins include ribosomes, nucleosomes, and viral nucleocapsid proteins.
    Nucleoprotein (N protein), the most antigenic hantavirus protein, is detectable early in the infection course and participates in the viral replication.
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