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OLR1
Anti-OLR1 Recombinant Antibody Products
- CytoStream™ Mouse Anti-OLR1 Recombinant Antibody (clone 15C4) (VS-0225-XY172)
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- Species Reactivity: Human
- Type: Mouse IgG2a, kappa
- Application: FC
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For Research Use Only. Not For Clinical Use.
OLR1 (Oxidized Low-Density Lipoprotein Receptor 1) encodes a receptor that binds oxidized LDL (oxLDL), playing a role in atherosclerosis. It is expressed in endothelial cells, macrophages, and smooth muscle cells, and its activation leads to the uptake of oxLDL, contributing to plaque formation in blood vessels. OLR1 has been studied as a potential biomarker for cardiovascular diseases and inflammation.
Protein class
Disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts, Macrophages, Hofbauer cells)
Immune cell specificity
Immune cell enhanced (myeloid DC)
Cell line specificity
Cell line enhanced (CACO-2, HaCaT, HHSteC, hTCEpi, SiHa, SK-BR-3)
Interaction
Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70. (Microbial infection) Binds to the head and beginning of the coiled stalk of N. meningitidis adhesin A (nadA) variant 3; binding can be abrogated by monoclonal antibodies against the specific regions of NadA. Binding occurs in protein microarrays, in solution and when LOX-1 is expressed on the cell surface.
Molecular function
Receptor
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