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PDE4B
Anti-PDE4B Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Oligodendrocytes, Oligodendrocyte precursor cells)
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Cell line enhanced (AN3-CA, HUVEC TERT2, NTERA-2, SK-MEL-30, TIME, U-266/84)
Interaction
[Isoform PDE4B5]: Interacts with DISC1.
Molecular function
Hydrolase
More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway