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PELP1
Anti-PELP1 Recombinant Antibody Products
- Human Anti-PELP1 Recombinant Soluble TCR (clone AH10) (scTCR-0859YC-S(P))
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- Species Reactivity: Human
- Epitope: RLHDLVLPL
- MHC: HLA-A2
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- Human Anti-PELP1 Recombinant Soluble TCR (clone OE9) (scTCR-0860YC-S(P))
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- Species Reactivity: Human
- Epitope: LVLPLVMGV
- MHC: HLA-A2
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- Recombinant Human Anti-PELP1 Soluble TCR (AH10) (ZIP-Fos/ZIP-Jun) (VS-0622-YF2153)
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- Species Reactivity: Human
- Epitope: RLHDLVLPL
- MHC: HLA-A2
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- Recombinant Human Anti-PELP1 Soluble TCR (OE9) (ZIP-Fos/ZIP-Jun) (VS-0622-YF2154)
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- Species Reactivity: Human
- Epitope: LVLPLVMGV
- MHC: HLA-A2
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- Recombinant Human Anti-PELP1 Soluble TCR (AH10) (C-Cys) (VS-0622-YF4861)
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- Species Reactivity: Human
- Epitope: RLHDLVLPL
- MHC: HLA-A2
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- Recombinant Human Anti-PELP1 Soluble TCR (OE9) (C-Cys) (VS-0622-YF4862)
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- Species Reactivity: Human
- Epitope: LVLPLVMGV
- MHC: HLA-A2
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- Recombinant Human Anti-PELP1 Soluble TCR (AH10) (KIH) (VS-0622-YF7569)
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- Species Reactivity: Human
- Epitope: RLHDLVLPL
- MHC: HLA-A2
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- Recombinant Human Anti-PELP1 Soluble TCR (OE9) (KIH) (VS-0622-YF7570)
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- Species Reactivity: Human
- Epitope: LVLPLVMGV
- MHC: HLA-A2
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For Research Use Only. Not For Clinical Use.
This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with HRS, RXRA, SUMO2, HDAC2, RB1 and STAT3. Interacts with PI3K, SRC and EGFR in cytoplasm. Interacts with ESR1, the interaction is enhanced by 17-beta-; the interaction increases ESR1 transcriptional activity (PubMed:11481323, PubMed:14963108). Interacts with CREBBP and EP300 in a ligand-dependent manner (PubMed:11481323). Forms two complexes in the presence of 17-beta-estradiol; one with SRC (via the SH3 domain) and ESR1 and another with LCK and ESR1 (PubMed:14963108). Interacts with histone H1 and H3 with a greater affinity for H1. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Core component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9. Interacts with BCAS3. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts (via PELP1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles (PubMed:21326211, PubMed:27814492).
Molecular function
Activator, Repressor
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