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PGA5

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Anti-PGA5 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
Protein class

Enzymes, FDA approved drug targets

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enriched (Exocrine glandular cells)

Immune cell specificity

Group enriched (intermediate monocyte, non-classical monocyte, classical monocyte)

Cell line specificity

Cell line enriched (BJ hTERT+)

Molecular function

Aspartyl protease, Hydrolase, Protease

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