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PLK1
Anti-PLK1 Recombinant Antibody Products
- CytoStream™ Mouse Anti-PLK1 Recombinant Antibody (VS-0225-XY179) (VS-0225-XY179)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG1, kappa
- Application: FC
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For Research Use Only. Not For Clinical Use.
PLK1 (Polo-Like Kinase 1) is a serine/threonine kinase involved in regulating cell cycle progression, particularly during mitosis. It plays a role in spindle formation, chromosome alignment, and cytokinesis. Due to its critical role in cell division, PLK1 is a target for cancer therapy, and its overexpression is often observed in various tumors, making it an oncogene in several cancer types.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids, Spermatocytes, Extravillous trophoblasts, Erythroid cells, Cytotrophoblasts)
Immune cell specificity
Immune cell enriched (T-reg)
Cell line specificity
Low cell line specificity
Interaction
Interacts with CEP170 and EVI5. Interacts and phosphorylates ERCC6L. Interacts with FAM29A. Interacts with SLX4/BTBD12 and TTDN1. Interacts with BUB1B. Interacts (via POLO-box domain) with the phosphorylated form of BUB1, CENPU and CDC25C. Interacts with isoform 3 of SGO1. Interacts with BORA, KIF2A and AURKA. Interacts with TOPORS and CYLD. Interacts with ECT2; the interaction is stimulated upon phosphorylation of ECT2 on 'Thr-444'. Interacts with PRC1. Interacts with KIF20A/MKLP2 (when phosphorylated), leading to the recruitment at the central spindle. Interacts (via POLO box domains) with PPP1R12A/MYPT1 (when previously phosphorylated by CDK1). Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2. Interacts with BIRC6/bruce. Interacts with CDK1-phosphorylated FRY; this interaction occurs in mitotic cells, but not in interphase cells. FRY interaction facilitates AURKA-mediated PLK1 phosphorylation. Interacts with CDK1-phosphorylated DCTN6 during mitotic prometaphase; the interaction facilitates recruitment to kinetochores. Interacts with CEP68; the interaction phosphorylates CEP68 (PubMed:25503564). Interacts (via POLO-box domain) with DCTN1 (PubMed:20679239). Interacts with CEP20 in later G1, S, G2 and M phases of the cell cycle; this interaction recruits PLK1 to centrosomes, a step required for S phase progression (PubMed:24018379). Interacts with HSF1; this interaction increases upon heat shock but does not modulate neither HSF1 homotrimerization nor DNA-binding activities (PubMed:15661742, 18794143). Interacts with HNRNPU; this interaction induces phosphorylation of HNRNPU in mitosis (PubMed:25986610). Interacts (via its N-terminus) to RIOK2 (PubMed:21880710). Interacts with KLHL22 (PubMed:24067371, 23455478).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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