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PRKACA
Anti-PRKACA Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IF, IHC
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- Rabbit Anti-PRKACA Polyclonal Antibody (MRO-2123-CN) (MRO-2123-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: IF, IHC, FC
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- Mouse Anti-PRKACA Recombinant Antibody (clone 2E3B7) (VS3-XY1298)
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- Type: Mouse IgG1
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- Mouse Anti-PRKACA Recombinant Antibody (clone 7H3A4) (VS3-XY1299)
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- Type: Mouse IgG1
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- Mouse Anti-PRKACA Recombinant Antibody (clone 2E4) (VS3-XY1300)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.
This enzyme is responsible for phosphorylating other proteins and substrates, changing their activity. Protein kinase A catalytic subunit (PKA Cα) is a member of the AGC kinase family (protein kinases A, G, and C), and contributes to the control of cellular processes that include glucose metabolism, cell division, and contextual memory.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, RAS pathway related proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cardiomyocytes, Theca cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2. Both isoforms 1 and 2 forms activate cAMP-sensitive PKAI and PKAII holoenzymes by interacting with regulatory subunit (R) of PKA, PRKAR1A/PKR1 and PRKAR2A/PKR2, respectively. Interacts with PRKAR1A and PRKAR2B (PubMed:33058759). Interacts with NFKB1, NFKB2 and NFKBIA in platelets; these interactions are disrupted by thrombin and collagen. Binds to ABL1 in spermatozoa and with CDC25B in oocytes. Interacts with APOBEC3G and AICDA. Interacts with RAB13; downstream effector of RAB13 involved in tight junction assembly. Found in a complex at least composed of MROH2B, PRKACA isoform 2 and TCP11 (By similarity). Interacts with MROH2B (By similarity). Isoform 2 interacts with TCP11 (By similarity). Interacts with HSF1 (PubMed:21085490).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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