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PSMA3
Anti-PSMA3 Recombinant Antibody Products
- AbPlus™ Anti-PSMA3 Magnetic Beads (VS-0724-YC1004) (VS-0724-YC1004)
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- Target: PSMA3
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes.
Protein class
Enzymes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits (PubMed:25599644, 26133119, 26657688, 27342858, 27428775, 27493187, 34711951). The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings (PubMed:25599644, 26133119, 26657688, 27342858, 27428775, 27493187, 34711951). The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits (PubMed:25599644, 26133119, 26657688, 27342858, 27428775, 27493187, 34711951). The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7 (PubMed:25599644, 26133119, 26657688, 27342858, 27428775, 27493187, 34711951). Interacts with AURKB (PubMed:14674694). Interacts with CDKN1A (PubMed:11350925). Interacts with MDM2 and RB1 (PubMed:16337594). Interacts with the C-terminus of TBXA2R isoform 2 (PubMed:17499743). Interacts with DNAJB2 (PubMed:15936278). (Microbial infection) Interacts with HIV-1 Tat protein. (Microbial infection) Interacts with hepatitis C virus (HCV) F protein. (Microbial infection) Interacts with Epstein-Barr virus EBNA3 proteins.
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