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PSMD10
Anti-PSMD10 Recombinant Antibody Products
- Mouse Anti-PSMD10 Recombinant Antibody (TAB-0912CL) (TAB-0912CL)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: IHC, WB
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- Mouse Anti-PSMD10 Recombinant Antibody (TAB-0913CL) (TAB-0913CL)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: IHC, WB
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- Mouse Anti-PSMD10 Recombinant Antibody; scFv Fragment (TAB-0912CL-S(P)) (TAB-0912CL-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: IHC, WB
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- Mouse Anti-PSMD10 Recombinant Antibody; scFv Fragment (TAB-0913CL-S(P)) (TAB-0913CL-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: IHC, WB
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- Mouse Anti-PSMD10 Recombinant Antibody; Fab Fragment (TAB-0912CL-F(E)) (TAB-0912CL-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: IHC, WB
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- Mouse Anti-PSMD10 Recombinant Antibody; Fab Fragment (TAB-0913CL-F(E)) (TAB-0913CL-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: IHC, WB
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For Research Use Only. Not For Clinical Use.
This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Part of transient complex containing PSMD10, PSMC4, PSMC5 and PAAF1 formed during the assembly of the 26S proteasome. Stays associated throughout the assembly of the PA700/19S RC and is released upon association with the 20S core. Interacts with PSMC4. Interacts with RB1. Interacts with CDK4. Interacts with MDM2. Interacts with RELA. Associates with a CDK4:CCND2 serine/threonine kinase complex. Interacts with ARHGDIA and increases the interaction between ARHGDIA and RHOA, hence promotes ARHGDIA inactivation of RHOA and ROCK.
Molecular function
Chaperone
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