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PVR
Anti-PVR Recombinant Antibody Products
- AbPlus™ Anti-PVR Magnetic Beads (VS-0724-YC1373) (VS-0724-YC1373)
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- Target: PVR
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
PVR (Poliovirus Receptor) encodes a cell surface protein that acts as a receptor for poliovirus, enabling viral entry into cells. Beyond its role in viral infection, PVR is involved in regulating immune responses and cell adhesion. It is expressed in various tissues, including the nervous system, and has been studied for its role in cancer metastasis and immune system regulation.
Protein class
CD markers, Plasma proteins
Predicted location
Intracellular, Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Pancreatic endocrine cells)
Immune cell specificity
Group enriched (non-classical monocyte, intermediate monocyte, classical monocyte, myeloid DC)
Cell line specificity
Cell line enhanced (TIME)
Interaction
Can form trans-heterodimers with NECTIN3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. Binds with high affinity to TIGIT. (Microbial infection) Interacts with poliovirus capsid proteins. (Microbial infection) Interacts with human cytomegalovirus /HHV-5 UL141 protein. (Microbial infection) Interacts with pseudorabies virus gD protein.
Molecular function
Host cell receptor for virus entry, Receptor
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