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RAD50
Loading...Anti-RAD50 Products
- Mouse Anti-NHP RAD50 Recombinant Antibody (clone 13B3) (VS-1024-XY431)
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- Species Reactivity: Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG1
- Application: WB, IHC, IF
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
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- Mouse Anti-RAD50 Recombinant Antibody (clone 3D2G10) (VS7-0425-WR759)
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- Species Reactivity: Human, Rat
- Type: Mouse IgG2a
- Application: WB, IHC, FC
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- Mouse Anti-RAD50 Recombinant Antibody (clone 5A8E5) (VS7-0425-WR758)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELSIA
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the MRN complex composed of two heterodimers RAD50/MRE11 associated with a single NBN (PubMed:8756642, PubMed:9590181, PubMed:9705271, PubMed:10839544, PubMed:26215093). As part of the MRN complex, interacts with MCM8 and MCM9; the interaction recruits the complex to DNA repair sites (PubMed:26215093). Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11 and NBN (PubMed:10783165). Found in a complex with TERF2 (PubMed:10888888). Interacts with RINT1 (PubMed:11096100). Interacts with BRCA1 via its N-terminal domain (PubMed:10426999). Interacts with DCLRE1C/Artemis (PubMed:15456891, PubMed:15723659). Interacts with MRNIP (PubMed:27568553). Interacts with CYREN (via XLF motif) (By similarity). (Microbial infection) Interacts with herpes simplex virus 1 protein UL12 (PubMed:20943970).
Molecular function
Hydrolase
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