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RGS2
Anti-RGS2 Recombinant Antibody Products
- Chicken Anti-RGS2 Polyclonal IgY (BRD-0502MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (granulocytes, Langerhans cells, Macrophages)
Immune cell specificity
Group enriched (neutrophil, basophil)
Cell line specificity
Cell line enhanced (hTCEpi, hTERT-HME1, Karpas-707, PC-3)
Interaction
Interacts with GNAQ (PubMed:18434541, PubMed:19478087, PubMed:28784619). Does not interact with GNAI1 and GNAI3 (PubMed:18434541, PubMed:19478087). Interacts with EIF2B5 (PubMed:19736320). Interacts with PRKG1 (isoform alpha) (PubMed:14608379).
Molecular function
GTPase activation, Signal transduction inhibitor
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