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RNASE1
Anti-RNASE1 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
Protein class
Enzymes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Hofbauer cells, Alveolar cells type 1, Adipocytes, Gastric mucus-secreting cells, Alveolar cells type 2, Intestinal goblet cells, Hepatic stellate cells, Macrophages)
Immune cell specificity
Immune cell enhanced (myeloid DC, classical monocyte)
Cell line specificity
Cell line enhanced (HUVEC TERT2, OE19, RT4, TIME)
Interaction
Monomer. Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein.
Molecular function
Endonuclease, Hydrolase, Lyase, Nuclease
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