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For Research Use Only. Not For Clinical Use.
Enzymes, Metabolic proteins, Plasma proteins
Intracellular
Cell type enhanced (dendritic cells, Cytotrophoblasts, Pancreatic endocrine cells)
Immune cell enhanced (plasmacytoid DC)
Low cell line specificity
Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA4 associates with and phosphorylates the NF-kappa-B p65 subunit RELA.
Kinase, Serine/threonine-protein kinase, Transferase