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RRM2

Anti-RRM2 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
Protein class

Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins

Predicted location

Membrane

Single cell type specificity

Group enriched (Extravillous trophoblasts, Plasma cells, Erythroid cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Heterodimer of a large and a small subunit. Interacts (via Cy motif and when phosphorylated at Thr-33) with CCNF; the interaction occurs exclusively in G2 and early M (PubMed:22632967).

Molecular function

Oxidoreductase

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