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For Research Use Only. Not For Clinical Use.
Intracellular
Low cell type specificity
Group enriched (plasmacytoid DC, NK-cell)
Cell line enhanced (Hep G2)
Interacts via its C-terminal region with the TAX1BP3 PDZ domain. This interaction facilitates Rho-mediated activation of the c-Fos serum response element (SRE). Interacts with SEPT9. Specifically binds to GTP-bound RHOA, RHOB and RHOC and inhibits their GTPase activity.