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SATB2
Anti-SATB2 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein.
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Distal enterocytes, Enteroendocrine cells, Undifferentiated cells, Paneth cells, Intestinal goblet cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HEL, K-562, THP-1)
Interaction
Interacts with ATF4 and RUNX2; resulting in enhanced DNA binding and transactivation by these transcription factors (By similarity). Interacts with PIAS1.
Molecular function
Chromatin regulator, Developmental protein, DNA-binding, Repressor
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