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SERPINA1
Anti-SERPINA1 Recombinant Antibody Products
- Chicken Anti-alpha-1 Antitrypsin Polyclonal IgY (BRD-0846MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enriched (Hepatocytes)
Immune cell specificity
Group enriched (non-classical monocyte, intermediate monocyte, neutrophil, classical monocyte)
Cell line specificity
Cell line enriched (Hep G2)
Interaction
Interacts with CELA2A (PubMed:31358993). Interacts with ERGIC3 and LMAN1/ERGIC53 (PubMed:31142615). Interacts with PRSS1/trypsin (PubMed:11057674). Interacts with PRSS1/Trypsin (PubMed:11057674). The variants S and Z interact with CANX AND PDIA3 (PubMed:23826168).
Molecular function
Protease inhibitor, Serine protease inhibitor
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