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SLC30A10

Anti-SLC30A10 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism.
Protein class

Disease related genes, Human disease related genes, Potential drug targets, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Distal enterocytes, Early spermatids, Late spermatids, Hepatocytes, Astrocytes, Paneth cells, Proximal enterocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (HEK93, HEL, K-562)

Interaction

Forms homodimers. Forms heterodimers and high-molecular weight oligomers with SLC30A3, SLC30A2 and SLC30A4; heterodimerization is mediated by covalent-bound tyrosine residues and occurs probably in a tissue-specific manner.

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