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For Research Use Only. Not For Clinical Use.
Intracellular
Cell type enhanced (Early spermatids, Spermatocytes)
Low immune cell specificity
Low cell line specificity
Forms a heterodimer with SMC5 (PubMed:11408570). Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3 (PubMed:18086888). Interacts with NSMCE1 (PubMed:14701739). Interacts with NSMCE2 (PubMed:16055714). Interacts with SLF1 (PubMed:25931565). Interacts with SLF2 (PubMed:25931565). Interacts with RAD18 (PubMed:25931565). (Microbial infection) SMC5-SMC6 complex interacts with Hepatitis B X protein.