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For Research Use Only. Not For Clinical Use.
Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors
Intracellular
Cell type enriched (Erythroid cells)
Not detected in immune cells
Cell line enhanced (HEL, HMC-1, HUVEC TERT2, JURKAT, K-562, MOLT-4, TIME)
Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with SBNO2; this interaction inhibits TAL1 occupancy of the DCSTAMP promoter, leading to the activation of the DCSTAMP promoter by the transcription factor MITF.
Developmental protein, DNA-binding